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Interview with 2019 grownup to monitor Lori Diachin, Deputy Director, Exascale Computing venture | Real Questions and Pass4sure dumps

HPCwire lately announced our 2019 americans to watch and should be working featured interviews with these 12 notion leaders and HPC influencers in the coming weeks. First up we're satisfied to bring you our interview with Lori Diachin, deputy director for the U.S. department of power’s Exascale Computing venture (ECP). Diachin joined the ECP remaining 12 months and he or she brings with her a a success music listing of challenge leadership and a deep dedication to research computing. She is additionally serving as the Deputy associate Director (DAD) for Science and expertise within the Computation Directorate at Lawrence Livermore countrywide Laboratory, and earlier than joining LLNL, become a pc scientist at Argonne countrywide Laboratory and a member of the technical team of workers at Sandia country wide Laboratory. Please also see Diachin’s video interview with ECP verbal exchange supervisor Mike Bernhardt (link).

HPCwire: hello Lori, congrats to your new position and your many accomplishments. What excites you about working in the DOE and Exascale Computing undertaking?

Lori Diachin: in the DOE, i'm enthusiastic about being part of a mission company, and the fact that what we are doing is crucial and applies to issues that definitely affect the nation. furthermore, there are various things to work on all the way through the direction of a career in the DOE and, for me, numerous labs to work at. I’ve been at three of the DOE country wide labs and have had numerous assignments through the years, which allows for continuous boom and profession revitalization. finally, the individuals I work with each day, such as the technical researchers, are in reality terrific.

For the ECP in specific what I’ve discovered definitely exciting is the undeniable fact that it’s one of the vital greatest and most crucial computing initiatives that the DOE has backed. We’re concentrated on constructing a in a position exascale computing ecosystem comprising software development, software technologies, and advanced hardware design. What we're doing might have a tremendous have an effect on on our nation; each from the point of view of the purposes we're setting up and the investments we are making to maintain the excessive performance computing ecosystem suit. In my current assignment, I work primarily work with the ECP management group many of whom I’ve established for many years and they are striking. They’re committed to what we’re doing and all very competent; it’s a superb group to work with. Doug Kothe, the ECP task director, has created a very collaborative dynamic that’s open and inclusive, and i really cost that group ambiance. I also really have fun with studying new issues, together with the broad technical scope of ECP and the intricacies of managing a such a huge, different analysis, construction, and deployment venture under formal DOE challenge administration instructions.

HPCwire: What features of the Exascale Computing venture are you focused on and what do you see as (a few of) ECP’s enjoyable strengths?

I even have simplest been with ECP for roughly six months so I’m relatively new to the trouble and so firstly I’ve been very concentrated on studying. discovering concerning the technical scope throughout the entire applications, getting to know greater concerning the software technologies that are being developed, and getting to know about formal task management practices within the DOE. currently, I’m settling in and i’m focused on lots of diverse points of undertaking administration in partnership with Doug Kothe. One instance can be integration across distinct ECP application points. There are about 1,000 researchers at sixteen distinctive laboratories engaged on over one hundred different subprojects within the ECP, tracking the integration that’s going on amongst all of these efforts is a fascinating problem. different contemporary activities encompass price range planning, improving our monthly reporting approaches, and getting ready for our last design assessment, which is developing this summer. because Doug is awfully inclusive, he brings me in on various features of the venture, and it’s actually been loads of fun.

when it comes to interesting strengths, so far as i know, the ECP is the largest computational science, computer science, and math project within the DOE designed to develop an integrated set of technologies for a capable exascale ecosystem. There are 25 utility teams focused on providing science problem complications that they couldn’t begin to address today. this could permit loads of new capabilities which are important for the nation within the areas of power, science, economic safety, and country wide safety. On the software facet there are some entertaining alternatives enabled by using the ECP because, for the primary time, we have such a huge integrated group that can all pull in one course. for example, we have the means to study DOE-developed utility and examine making it extra with no trouble accessible to end users. here is completed throughout the definition of community policies that enable interoperability, along with the creation of software development tool kits and continual integration practices that enable more convenient, turnkey entry to numerical libraries, developer productiveness equipment, and statistics and visualization analysis concepts. this is whatever that we haven’t had a lot vital mass round in previous projects, and the dimensions of this effort is really wonderful.

HPCwire: What impressed you to pursue a profession in STEM and what counsel would you provide to younger americans wishing to follow for your footsteps?

My father was a professor of math training, so turning out to be up there become lots of emphasis on science and math. This led me to get my BA in math. I learned a fair quantity of thought with that diploma, however I didn’t know the most beneficial approach to follow it. due to this fact, I decided to continue my education in graduate college and get my diploma in utilized arithmetic. Graduate faculty is the place I first fell in love with the conception of numerical methods and the way they may also be used to remedy actually difficult physics complications with the aid of breaking them down into smaller pieces that are less demanding to solve on high performance computer systems. this is what i finished up specializing in for my dissertation, for my post doc, and for my first a couple of years at Argonne country wide Lab (ANL).

Early in my career at ANL, i realized that whereas I enjoyed the technical work, I had a good more desirable passion for the management of science. So after about 10 years on the technical track, I began to focal point extra on mission, line, and program administration. That’s what I’ve been doing the final 20 or so years; increasing my tasks in these areas where I agree with my competencies are doubtless most desirable applicable.

after I first expressed hobby in pursuing a profession in scientific administration, i was given the information to set up my credentials as a scientist first. I progressively took on further and further undertaking responsibilities, better tasks, and multi-institutional groups. I took on line management responsibilities here at Lawrence Livermore national Lab (LLNL) starting with 15 people and scaling to about four hundred people. I’ve carried out various issues in software management at LLNL together with managing our portfolio of internally directed research tasks serving because the director of the DOE HPC4Manufacturing program.

aside from following the guidance given to me to set up their technical credentials before pursing administration, i might recommend younger individuals to respect and embody their entertaining strengths. It’s the variety in our skill sets that makes a group and corporation more suitable. you are dependable to your personal career, so figure out what you're enthusiastic about, what you're respectable at, and pursue the assignments and alternatives that spotlight these skills. one other element that truly helped me turned into discovering a superb mentor who became doing a job i thought i might relish doing. I talked to that grownup appreciably about how they obtained to the place they had been and how I could do anything identical. His suggestions become, and still is, priceless. I feel awesome mentorship really makes a difference.

HPCwire: generally speakme, what traits and/or technologies in high-performance computing do you see as peculiarly critical for the next 5 years?

we are increasingly in an era the place we now have greater really good processors and where we’re using diverse processors together within a device. here's leading to a great deal extra heterogeneous computing, which has big implications on our programming fashions, construction equipment, libraries, workflows, and functions.

one of the crucial pleasing facets of this for me is that algorithms that had been dismissed 20 or 30 years in the past are being revisited on account of the style architectures are changing. as an example agree with excessive order numerical discretization methods. When memory turned into free and flops have been costly, excessive order strategies were seen as too expensive relative to the extra accuracy achieved and so researchers generally disregarded strategies bigger than 2nd order as no longer worth the computational cost. Now that facts stream is awfully high priced and the computing is “free”, researchers are discovering that a great deal higher-order methods return more advantageous arithmetic intensity, and hence value, for the information motion that is needed. At LLNL, we’re seeing very good outcomes with these methods and i predict they will gain much more traction in the years to come. This conception that the historic algorithms have become new once more is what I find exciting.

one more factor that need to be outlined to maintain an eye on is explosion of facts science. there are many organizations and industries exploring statistics science thoughts; what I’m most attracted to is how we will leverage facts science concepts to enhance and increase the scientific endeavors the DOE cares about, as an instance, actual science experiments or enormous-scale simulations that model actual approaches.

HPCwire: outside of the skilled sphere, what can you inform us about yourself – very own life, household, historical past, events, and so forth.? Is there anything about you your colleagues might possibly be surprised to be trained?

I’ve been married for 22 years, don’t have any youngsters but a lot of nieces and nephews who are exquisite. What’s dominated my very own life most currently is a massive remodel on a 1940’s home in downtown Livermore, which we are just finishing now. when it comes to movements, i really like to read, in most cases fiction of all different genres. i love to draw and that i’m at present trying to master watercolors, despite the fact I’m no longer very first rate at it yet. i like decent meals, respectable wine, and, increasingly, craft cocktails. I feel frequently times americans are stunned to gain knowledge of I even have an artistic aspect. I just about majored in art in college, but I couldn’t quite figure out how that could pay the expenses so I majored in math in its place, and now, right here i am.

AVATA Receives Oracle Cloud Excellence Implementer software recognition for give Chain management Cloud | Real Questions and Pass4sure dumps

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Wealth Receives nice Geophysical results for the Vapor Lithium Brine venture, Northern Chile and offers corporate replace | Real Questions and Pass4sure dumps

VANCOUVER, British Columbia, Feb. 28, 2019 (GLOBE NEWSWIRE) -- Wealth Minerals Ltd. (the “company” or “Wealth”) - (TSXV: WML; OTCQX: WMLLF; SSE: WMLCL; Frankfurt: EJZN), stories that it has obtained effective outcomes from geophysical surveys performed on and around certain concessions in the enterprise’s Vapor project (the “Vapor assignment”), located within the Ollague Salar, and has recognized excessive-priority drill goals for 2019 (see press unencumber dated February 11, 2019).

“The extraordinarily low resistivity alerts at the Vapor assignment represents a neighborhood of approximately 5,200 hectares. With this low sign extending all the way down to at least 500 meters beneath surface, it appears that Vapor is a challenge with high advantage; an opinion strongly supported by drill outcomes from different explorers in the salar” pointed out Henk van Alphen, Wealth’s CEO.

Geophysical Survey outcomes

The Transient Electromagnetic (“TEM”) surveys (figure 1) identified highly conductive zones, that are interpreted to represent porous media with high-salinity fluids (potentially lithium-bearing brines) at depth.  multiple anomalies are identified in the survey enviornment with a number of advantage drill objectives.  On the basis of TEM records, Line four (determine 2) represents the maximum precedence target with the highest tenor conductivity (lowest resistivity) suggesting potentially superior saturation and/or potentially greater salinity.

The survey turned into achieved by Southernrock Geophysics S.A. and consisted of a total of 90 stations of 250m coincident loop TEM sites found along four lines (determine 1).  statistics turned into processed in keeping with average methodologies and 1D inversion modelling turned into used to generate compiled sections and 3D visualizations. 1D inversion modelling has supplied reasonably powerful pictures of the subsurface resistivity characteristics to around 500m depth from surface.  A median resistivity of two.2 Ωm all the way through the modelled interval alongside all lines illustrates the very conductive subsurface ambiance, often with a big intervals of lower than 1 Ωm.

pictures accompanying this announcement can be found at:

assignment background

The Vapor challenge carries 5,200 hectares discovered in northern Chile, place II, close the Chile-Bolivia border. contemporary drilling exercise via a peer enterprise in the area lower back lithium grades as much as 480 Li mg/l and floor sampling has lower back lithium grades as excessive as 1,140 Li mg/l.  Readers are suggested that the residences held through a peer enterprise are adjoining residences and that Wealth has no interest in or right to acquire any pastime in any half of these residences, and that mineral deposits on adjacent or similar properties aren't in any approach indicative of mineral deposits on Wealth’s mineral properties or place in the Ollague salar.

Atacama payment

As introduced on February eleven, 2019, Wealth renegotiated the charge schedule for the Atacama assignment as at the start announced on November 23, 2016. The fee of USD 500,000 and the difficulty of 5,000,000 usual shares has been accomplished. The next payment of USD 2,000,000 is due March 31, 2019.

PDAC conference

Wealth is participating within the PDAC 2019 conference to be held in Toronto, Ontario from March 3-6, 2019 on the Metro Toronto convention Centre. Wealth Minerals could be in sales space 3141 at the traders trade. crew individuals could be obtainable to answer questions. interested parties that want to agenda a gathering, or who would really like more tips related to the conferences and routine mentioned above, please contact Michael Pound at (604) 638 3665, or e-mail corporate presentation and reality sheet tips substances are available on the enterprise’s website at

certified adult

Keith J. Henderson, P.Geo, a qualified person as defined with the aid of country wide Instrument 43-a hundred and one standards of Disclosure for Mineral initiatives, has reviewed the scientific and technical suggestions that types the foundation for the technical disclosure in this information free up. Mr. Henderson is not impartial of the company as he is a shareholder, a expert to the company and holds incentive stock alternatives of the business.

About Wealth Minerals Ltd.

Wealth is a mineral aid business with pastimes in Canada, Mexico, Peru and Chile. The enterprise’s leading center of attention is the acquisition and construction of lithium tasks in South the us. to date, the enterprise has placed itself to enhance the Quisquiro Salar in Chile (the Trinity venture), as well as to work alongside present producers in the prolific Atacama Salar, the place the company has a substantial licenses kit. The enterprise has also positioned itself to play a job in asset consolidation in Chile with quite a few lithium houses all the way through the country.

Lithium market dynamics and a unexpectedly expanding steel price are the outcome of profound structural issues with the industry meeting anticipated future demand. Wealth is positioning itself to be a massive beneficiary of this future mismatch of supply and demand. The company also keeps and continues to evaluate a portfolio of valuable and base steel exploration-stage tasks.

For further particulars on the enterprise readers are observed the business’s site ( and its Canadian regulatory filings on SEDAR at

On Behalf of the Board of administrators ofWEALTH MINERALS LTD.

"Hendrik van Alphen"Hendrik van AlphenChief executive Officer

For additional advice, please contact:Marla RitchiePhone: 604-331-0096 Ext. 3886 or 604-638-3886E-mail:

Neither TSX mission exchange nor its legislation functions company (as that term is defined in the guidelines of the TSX task exchange) accepts responsibility for the adequacy or accuracy of this information release.

Cautionary word concerning ahead-searching Statements

This news release contains ahead-searching statements and forward-searching information (at the same time, “forward-searching statements”) within the meaning of relevant Canadian and U.S. securities law, including the us deepest Securities Litigation Reform Act of 1995. All statements, other than statements of historical reality, included herein together with, without limitation, predicted exploration program outcomes from exploration activities on the Vapor mission and the company’s task generally, the business’s expectation that it may be capable of enter into agreements to purchase interests in additional mineral properties, the discovery and delineation of mineral deposits/supplies/reserves and the predicted business plans and timing of future activities of the business, are ahead-searching statements. youngsters the business believes that such statements are reasonable, it can provide no assurance that such expectations will prove to be relevant. forward-searching statements are typically identified through phrases reminiscent of: “trust”, “predict”, “anticipate”, “intend”, “estimate”, “postulate” and identical expressions, or are those, which, via their nature, seek advice from future pursuits. In making the forward-searching statements in this information unencumber, the enterprise has utilized a number of cloth assumptions, together with without challenge, that market fundamentals will outcomes in sustained lithium demand and prices, the receipt of any essential allows for, licenses and regulatory approvals in connection with the long run development of the business’s Chilean lithium projects in a timely method, the provision of financing on relevant terms for the construction, construction and persisted operation of the company projects, and the business’s ability to agree to environmental, health and defense legal guidelines.

The company cautions traders that any forward-looking statements through the enterprise are not guarantees of future consequences or efficiency, and that precise outcomes may also differ materially from those in forward-looking statements on account of quite a few components, including, operating and technical difficulties in reference to mineral exploration and building activities, genuine results of exploration activities, the estimation or recognition of mineral reserves and mineral components, the timing and amount of estimated future production, the costs of production, capital charges, the fees and timing of the building of recent deposits, requirements for extra capital, future costs of lithium, adjustments in frequent economic conditions, alterations in the economic markets and within the demand and market price for commodities, lack of investor pastime in future financings, the proven fact that the company’s pursuits in its mineral properties (including the Vapor project and the Atacama venture) are options simplest and there is no make sure that the company’s interests in same, if earned, will be certain, accidents, labour disputes and other hazards of the mining industry, delays in obtaining governmental approvals, enables or financing or within the completion of development or construction activities, changes in laws, rules and guidelines affecting mining operations, title disputes, the inability of the business to reap any necessary allows, consents, approvals or authorizations, together with acceptance via the TSX assignment exchange required for the acquisition of extra mineral homes, the timing and feasible result of any pending litigation, environmental issues and liabilities, and dangers regarding three way partnership operations, and other dangers and uncertainties disclosed within the company’s latest interim management discussion and evaluation and filed with certain securities commissions in Canada. all the enterprise’s Canadian public disclosure filings may be accessed by the use of and readers are advised to evaluate these substances, including the technical experiences filed with appreciate to the enterprise’s mineral homes.

Readers are suggested not to place undue reliance on ahead-searching statements. The enterprise undertakes no duty to replace any of the forward-searching statements during this news unencumber or incorporated by reference herein, apart from as in any other case required by means of legislations.

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ALL, Accor’s new lifestyle loyalty program, becomes Principal Partner and jersey sponsor of Paris Saint-Germain Football Club | real questions and Pass4sure dumps

Press Release26 February 2019 accorhotels2017

Accor and Paris Saint-Germain today announce they have signed a global multi-year partnership agreement. ALL (Accor Live Limitless), Accor's new lifestyle loyalty platform, will become the Principal Partner and official jersey sponsor of the club starting from the 2019/2020 season. The partnership will bring together a global, pioneering leader in the hospitality industry with the world's fastest-growing football club; Accor's 265 million guests join the 395 million fans who follow the club and its players on social media worldwide.

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Behind the Seizure™ Program Expansion Helps Speed the Diagnosis of Genetic Epilepsy in Younger Children Experiencing Unprovoked Seizures | real questions and Pass4sure dumps

--Stoke Therapeutics and Xenon Pharmaceuticals Join Founders BioMarin and Invitae to Offer a No-Cost Epilepsy Gene Panel Testing Program for Children Up to 60 Months Who Have Had an Unprovoked Seizure--

SAN FRANCISCO, Feb. 26, 2019 /PRNewswire/ -- As Rare Disease Day focuses attention on the challenges of diagnosing rare, often genetic conditions, BioMarin Pharmaceutical Inc. (BMRN), Invitae Corporation (NVTA), Stoke Therapeutics and Xenon Pharmaceuticals (XENE) today announced the expansion of Behind the Seizure, an innovative, cross-company collaboration that aims to provide faster diagnosis for young children with epilepsy. Previously available to patients ages 2-4 years, the program will expand eligibility to make no-cost genetic testing available for healthcare providers to order for children who have had an unprovoked seizure from birth up to age five (0 to 60 months).

Invitae's (NVTA) mission is to bring comprehensive genetic information into mainstream medical practice to improve the quality of healthcare for billions of people. (PRNewsFoto/Invitae Corporation)


"Genetic testing can be invaluable in helping families and healthcare providers better understand how to care for children living with epilepsy," said Amy Brin Miller, executive director and chief executive office of the Child Neurology Foundation. "We applaud this unique effort to bring multiple partners together to help increase access to genetic testing for more of their patients, including their youngest ones."

Since the program began, hundreds of children have received genetic testing through Behind the Seizure and research has shown participants in the program were diagnosed 1-2 years sooner than historic averages.1

"Through this program we can secure comprehensive genetic testing for a child who has had an unprovoked seizure at no cost to the patient. That testing helps us get to a diagnosis faster so we can focus on providing the most accurate and timely treatment for our patients," said Raman Sankar, M.D., professor and chief of pediatric neurology at UCLA Mattel Children's Hospital in Los Angeles. "When dealing with such young patients, this type of program can be very important, shortening the time to diagnosis, particularly for neurodegenerative conditions such as CLN2 disease."

Partners in the program sponsor the cost of testing using the Invitae Epilepsy Panel, which includes up to 180+ genes associated with both syndromic and non-syndromic causes of epilepsy, including neurodegenerative conditions. With the expansion of the program, healthcare providers can now order the test for patients under the age of five with unprovoked seizures. Test results are available quickly (14 days on average).

"For many of the genetic disorders which cause serious debilitating morbidities in young children, early diagnosis is of paramount importance, and targeted early genetic testing is one way to overcome the challenges of delayed diagnosis. Over the years we've heard from physicians, advocacy groups, and parents about the challenges they face in implementing genetic testing early, to provide accurate and timely diagnosis that enables them to tailor their patients' care," said Adrian Quartel, group vice president and head of medical affairs for BioMarin. "We're proud to be working with our partners to further expand the Behind the Seizure program and foster earlier genetic testing – especially for the youngest patients."

Story continues

"More than half of epilepsies are based in genetics. When a child experiences a seizure, performing genetic testing quickly using a comprehensive gene panel is a highly cost-effective and informative diagnostic tool. Quickly finding an underlying cause for infantile epilepsy can be crucial for making a difference for that patient with precision management and treatment options," said Robert Nussbaum, M.D., chief medical officer of Invitae. "We're proud to partner with BioMarin, Stoke and Xenon to help more children get access to genetic testing sooner."

"At Stoke, we're focused on developing therapies that address the root cause of genetic epilepsies, starting with Dravet syndrome. As precision medicines become available, it is increasingly important for patients to get early and accurate genetic testing so they can be matched with the appropriate treatment. That's why we're delighted to support this critical expansion of the Behind the Seizure program," said Ed Kaye, M.D., chief executive officer of Stoke Therapeutics.

"Xenon is proud to be part of the Behind the Seizure collaboration, which aims to rapidly identify the genetic cause of seizures in children, including KCNQ2 and SCN8A epileptic encephalopathies. By offering this genetic testing to very young patients, it is hoped that the results will lead to earlier diagnoses and improved treatment outcomes through the introduction of personalized medicine approaches," said Simon Pimstone, M.D., chief executive officer of Xenon Pharmaceuticals.

To learn more about the Behind the Seizure program please visit

About BioMarinBioMarin is a global biotechnology company that develops and commercializes innovative therapies for patients with serious and life-threatening rare and ultra-rare genetic diseases. The company's portfolio consists of seven commercialized products and multiple clinical and pre-clinical product candidates. For additional information, please visit

About InvitaeInvitae Corporation (NVTA) is a leading genetics company whose mission is to bring comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. Invitae's goal is to aggregate the world's genetic tests into a single service with higher quality, faster turnaround time, and lower prices. For more information, visit the company's website at

About Stoke TherapeuticsLaunched in 2018, Stoke Therapeutics is a biotechnology company working to increase gene expression to treat a wide array of severe genetic diseases, including genetic conditions affecting the central nervous system, eye, liver and kidney. Stoke's lead program addresses Dravet syndrome, one of the more common causes of genetic epilepsy. Stoke has raised $130 million in funding from two rounds of financing; investors include Apple Tree Partners, RTW Investments, RA Capital Management, Cormorant Asset Management, Perceptive Advisors, funds managed by Janus Henderson Investors, Redmile Group, Sphera Funds Management, and Alexandria Venture Investments. For more information, visit and follow Stoke on Twitter @StokeTx.

About Xenon PharmaceuticalsXenon Pharmaceuticals is a clinical stage biopharmaceutical company committed to developing innovative therapeutics to improve the lives of patients with neurological disorders, including rare central nervous system (CNS) conditions. We are advancing a novel product pipeline of neurology therapies to address areas of high unmet medical need, with a focus on epilepsy. For more information, please visit

Safe Harbor StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to the benefits of genetic testing and the Behind the Seizure program, including shortening the time to diagnosis and improved treatment outcomes for patients. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially, and reported results should not be considered as an indication of future performance. These risks and uncertainties include, but are not limited to: the company's ability to use rapidly changing genetic data to interpret test results accurately and consistently; the ability of genetic testing to result in faster or more accurate diagnosis; laws and regulations applicable to the company's business; and the other risks set forth in Invitae's filings with the Securities and Exchange Commission, including the risks set forth in its Quarterly Report on Form 10-Q for the quarter ended September 30, 2018. These forward-looking statements speak only as of the date hereof, and Invitae Corporation disclaims any obligation to update these forward-looking statements.

Contact:Laura D' 213-3283

1Miller, Nicole, et al, "Behind the Seizure: A No-Cost 125-gene Epilepsy Panel for Pediatric Seizure Onset Between 2–4 Years." Presented at the American Society of Human Genetics Meeting: October 16–20, 2018, San Diego, CA.


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